Features of the Distribution of Allelic Polymorphism of Folate Cycle Genes in Women with a Burdened Obstetric History

Authors

  • Dilfuza Yangibayeva Obstetrics and gynecology in family medicine department, Tashkent medical academy, Tashkent, Uzbekistan
  • Gulchekhra Choriyeva Obstetrics and gynecology in family medicine department, Tashkent medical academy, Tashkent, Uzbekistan

Keywords:

congenital malformations of the fetus, undeveloped pregnancy, folate exchange

Abstract

The study analyzed polymorphisms of folate cycle genes (MTHFR, MTR, MTRR) in women with congenital malformations (CM) of the fetus and non-viable pregnancy. It was found that the homozygous mutant genotype C/C (Glu429Ala, MTHFR) was found 2.5 times more often in the group of women with CM of the fetus than in the control group. The genotype G/G (Ile22Met, MTRR) was found 4.6 times more often in women with CM of the fetus compared to the control. The obtained data confirm the role of mutations in folate cycle genes in the development of reproductive complications, and also indicate the need to take into account endo- and exogenous factors that contribute to their implementation.

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Published

2025-06-20

Issue

Vol. 3 No. 6 (2025): American Journal of Pediatric Medicine and Health Sciences

Section

Articles

How to Cite

Features of the Distribution of Allelic Polymorphism of Folate Cycle Genes in Women with a Burdened Obstetric History. (2025). American Journal of Pediatric Medicine and Health Sciences (2993-2149), 3(6), 93-97. https://grnjournal.us/index.php/AJPMHS/article/view/8011