Chronic Autoimmune Endometritis as the Main Cause of Reproductive Disorder

Abstract

The main role of inflammatory diseases of the internal genital organs in the structure of the reproductive function of women, as well as chronic endometritis, as a cause of infertility of uterine genesis, which tends to steadily increase. Etiological risk factors for the development and trigger mechanism of chronic inflammatory processes in the endometrium, features of the pathogenesis and clinical picture of endometritis are identified. Criteria for morphological diagnostics of endometritis, morphological signs of endometritis with an autoimmune nature of the inflammatory process, various extranosological structural and functional disorders in the endometrium are determined. The significance of diagnostics of autoimmune chronic endometritis by the immunohistochemical method, the expediency of immunohistochemical study for assessment of receptor expression and severity of local immunity in the endometrium, the necessity of determination of the fertility protein alpha-2-microglobulin, the presence of pathogenic bacterial and viral microflora in the vagina, cervical canal and in the uterine cavity in the aspect of prevention of reproductive losses and treatment of infertility of uterine genesis are shown. The necessity of synchronization of processes of differentiation of endometrial cells and embryogenesis, the influence of sex steroids on the endometrium are specified.