Effect of Sleep Quality in Amyloid Plague Accumulation in Alzheimers

Abstract

This study examined the effect of sleep quality in amyloid plague accumulation in alzheimers disease. The study mentioned that Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory impairment, and the accumulation of amyloid-beta (Aβ) plaques in the brain. In carrying out this research, the following subheads were explored: concept of sleep, concept of sleep quality, concept of amyliod plague accumulation and concept of alzheimer’s disease. The need for sleep quality as mentioned in the study included: for improved mood, for healthy heart and to regulated blood sugar. Similarly, the study mentioned the effects of sleep quality in amyloid plague accumulation in Alzheimer to include: impaired glymphatic clearance of amyloid-beta, increased tau protein accumulation and APOE-ε4 /sleep disruptions in alzheimer's risk. Furthermore, the study mentioned cognitive behavioral therapy for insomnia (CBT-I), melatonin supplementation and physical activity/ exercise how to improve sleep quality. The study concluded that emerging evidence highlights the crucial role of sleep quality in regulating amyloid-beta accumulation and the progression of Alzheimer’s disease. One of the recommendations made was that public health initiatives should raise awareness about the importance of sleep in brain health.