Modern View on the Role of Hyperhomocysteinemia in Cognitive Dysfunction

Abstract

Homocysteine is an amino acid produced by methionine metabolism, a process
dependent on B vitamins, cobalamin, vitamin B6 and folic acid. There is evidence that elevated
serum homocysteine levels are associated with cognitive decline and dementia. We review these
data in addition to potential mechanisms by which homocysteine acts in the brain to cause
cognitive dysfunction, homocysteine metabolism, and factors associated with altering normal
metabolism