Immunological Aspects of the Development of Oral Lesions in Inflammatory Bowel Disease

Abstract

According to modern concepts, immune disorders play one of central roles in the pathogenesis of IBD. The main immunopathological mechanism is an imbalance between subpopulations of CD4 cells: Th1- and Th2- lymphocytes. According to most authors, CD and UC differ in types cellular immune response. CD is characterized by a cell-mediated reaction of immune damage to the intestinal wall of the Th1 type with a predominance of eat CD4+ - and CD8+ -cells. UC is thought to be a Th2 disease. Type with an increase in the population of B-lymphocytes (CD19 and CD20) and plasma cells resulting from the development of humoral immunity. According to other scientists, in UC there are violations of both humoral, and cell-mediated immunity. Considering different types development of the immune response, immunohistochemical studies of cell composition of lymphocytes are of practical value in the differential diagnosis of CD and UC.