Study of the Effect of Gender on Some Biochemical Parameters in Elderly Patients with Cardiovascular Diseases in Thi Qar, Iraq

Abstract

Cardiovascular diseases (CVD) are among the most well-known causes of death in the elderly. These conditions include ischemic heart disease, stroke, and several other cardiac and vascular diseases, all affecting the heart and circulatory system. This study aimed to evaluate the effect of sex on levels of oxidized low-density lipoprotein (OxLDL), malondialdehyde (MDA) in elderly patients (ages 60-79) with CVD, compared with other patients (ages 20–59) with the same disease, as well as control groups of the elderly and others. Samples of blood were collected from sixty patients of both sexes with CVD. These patients were divided into two age groups: the first group consisted of thirty elderly patients (15 males/15 females), while the second group comprised thirty other patients (18 males/12 females). The study also included a control group of apparently healthy individuals, who were similarly divided into 30 elderly individuals (15 males/15 females) and 30 other individuals (14 males/ 16 females). The results showed a significant increase in MDA concentration in the serum of elderly female cardiovascular patients compared to male patients of the same age group (p<0.05). However, there was no significant difference in serum concentration of OxLDL between the sexes in the other patient and healthy groups. Within each sex, significant differences were found between patients and healthy individuals across all age groups (p≤0.05). Assessing oxidative stress parameters in each age group, in both females and males, may contribute to predicting cardiovascular disease and help determine the level of risk.