Negative Effects of Antituberculous Drugs for Patients with Combination of Tuberculosis and Сovid-19

Abstract

Hepatobiliary system of patients with tuberculosis suffers by different reasons: tuberculous intoxication, taking of antituberculosis drugs with high hepatotoxic activity, joining coronavirus infection. The purpose of our research was a study of structure of hepatotoxic reactions at children and adolescents, consumptive at combination with a coronavirus infection (SARS CoV - 2). Materials and methods: 26 children and adolescents are inspected with tuberculosis of intrathoracic lymphatic nodes in the stage of infiltration, treatings in the Samarkand center of phthisiology and pulmonology.

In a basic group (I) 13 is plugged patients with the confirmed concomitant coronavirus infection of SARSCoV - 2, in the group of comparison (II) ‒ 13 patients by tuberculosis of children and adolescents without by a concomitant Sars-CoV-2. In the process of treatment with antituberculosis preparations children and adolescents with combination of tuberculosis and coronavirus infection the side effects of drugs on a liver, gall-bladder and spleen were observed approximately 3,7 time more frequent, than in a group with the isolated tuberculosis. Side toxic effect of antituberculosis drugs in I to the group of children were educed on a 15 twenty-four hours before from the beginning of therapy, their relapses were registered in 1,8 time more frequent. For patients by tuberculosis with combination of Sars-Cov-2 toxic influence of drugs on a liver resulted in more heavy flow of side effects : often educed clinically, obviously there was violation of structure of cages of hepatic parenchima, more frequent found out the phenomena of cholestasia, to portal hypertension, in addition a change took place in fabrics of pancreas. In addition stagnation and increase was more frequent registered pressure in the portal system of vessels; violation of motor activity of gall-bladder.