Dysmetabolic Nephropathy and Clinical Definition of Functional Kidney Reserve in Children

Abstract

A major achievement of nephrology in the last 10-15 years was the clinical and
experimental substantiation of the position that the progression of renal failure is more due to
secondary hemodynamic and metabolic factors than to the activity of the primary pathological
process. Unmodified and potentially modifiable risk factors for the progression of renal failure
have been identified (2,7). So, dynamic observation for 6 years for 76 children who underwent
nephropathy during the neonatal period. It showed that the majority of them, against the
background of ongoing rehabilitation measures, later develop interstitial nephritis (IN), neurogenic
bladder dysfunction or metabolic nephropathy and pyelonephritis. So, dynamic observation for 6
years for 76 children who underwent nephropathy during the neonatal period. It showed that most
of them, against the background of ongoing rehabilitation measures, subsequently develop
interstitial nephritis (IN), neurogenic dysfunction of the bladder or metabolic nephropathies and
pyelonephritis. Among the potentially reversible risk factors for the progression of renal failure, a
high value is attached to glomerular hyperfiltration and intraglomerular hypertension under the
influence of angiotensin II (ANG II).