Method for Determining Clinical and Immunological Disorders in Acute Pancreatitis

Abstract

In recent decades, the number of patients with acute pancreatitis has increased markedly in many countries of the world, and the quality of diagnosis has improved. Due to improved diagnostics, pancreatitis has become registered quite often: from 1 to 11% of all patients with acute abdominal diseases. Objective of the study: Improvement of methods for predicting surgical treatment of acute pancreatitis based on the study of clinical and immunological features of the course of the disease. Material and methods. The study was conducted in the Laboratory of Reproduction Immunology of the Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan in the period from 2020 to 2023. The study included 66 patients aged 25 to 65 years with the diagnosis of acute pancreatitis of non-alcoholic origin with an abortive course (41 patients) and acute pancreatitis of non-alcoholic origin with a progressive course (25 patients). Analysis of the results and discussion. The pancreas provides secretion of hormones and synthesis of digestive enzymes and is thus both an endocrine and exocrine gland. Many factors (gallstones, alcohol, blunt abdominal trauma) adversely affect the pancreas and lead to the development of pancreatitis. A comprehensive evaluation of these clinical and laboratory markers is used in the differential diagnosis and assessment of the severity of pancreatitis. Conclusion. A clinical, instrumental and laboratory study of patients with an established diagnosis of acute pancreatitis of non-alcoholic origin with abortive and progressive course was conducted.