Clinical Manifestations of Different Histological Variants of Breast Carcinoma

Abstract

Introduction: The article conducted a retrospective analysis of medical histories and
outpatient records of 1650 patients with breast cancer. An increase in the ability to metastasize has
been established in poorly differentiated tumors compared to more mature forms. At the same
time, the morphological aspect of metastasis in breast cancer has not been sufficiently studied, and
studies devoted to this issue are few.
Objective: To determine the survival prognosis depending on the histological type of
breast cancer.
Materials and methods: The study involved personal observations of patients, analysis of medical
histories and outpatient records of patients treated at the Samarkand branch of the Russian National
Medical Research and Medical Center from 2017 to 2022. During this time, 1650 patients with
primary breast cancer were treated.
Results: Depending on the stage of the process for Paget's breast cancer, patients were
distributed as follows: I T 1, 2 N 0 M 0 y 6, II a T 2 N 0 M 0 y 13, II B, T 2 N 1 M 0 -y 5, III a T 3 N 0 M
0 y 4, III B, T 1,2,3 N 1,2 M 0 y 6.
During a clinical examination of patients, the tumors had a lumpy surface and a dense consistency;
2 patients had dense, enlarged axillary lymph nodes. 7 patients had I - II a, T 2 N 0 M 0 stage of the
process, 2 - III b, T 2-3 N 1-2 M 0 . The frequency of metastasis was 16.5%, information on 5-year
survival is available for 2 patients, for the rest the duration of observation of patients continues.
Conclusion: The most common histological form (50%) was Paget's cancer , characterized by a
slow course, high 3 and 5 year survival of patients with locally advanced processes.