The Role of G/A Polymorphism of the F7 Factor Gene in the Genesis Unsuccessful IVF

Abstract

The article presents the results of molecular genetic studies of the G/A polymorphism of the F7 gene in 90 unsuccessful IVF women with thrombophilia. The results of the study showed that allele A and hetero-G/A and homozygous non-functional A/A genotypes of the F7 polymorphism are one of the markers of an increased risk of developing thrombophilia in women of the Uzbek population. And the functional allele G and the functionally favorable genotype G/G are functional genotypes in relation to the development of pathology (χ2=15.48; p<0.0004; OR=0.03; 95%CI0.00 – 0.46).