Specific Diagnostic Symptoms in GDM in Pregnant Women

Abstract

Data from a comparative analysis of specific diagnostic symptoms in GDM in pregnant women, for a detailed description of changes in the body of a pregnant woman with GDM, we studied the concentration of homocysteine in the blood for comparison in two study groups - 36 healthy and 68 pregnant women with GDM. According to the analysis of blood in the case histories of patients in groups, anemia was observed in an average of 61.45% of patients.

Based on the above data, using the Microsoft Excel 2010 program, a series of variations was built to find M±m indicators of the degree of dependence of these features, their correlation levels were studied by the Spearman method.

Homocysteine is a biomarker that controls the action of folic acid in the body in pregnant women, the reference values of which are in the range of 5.6–16.42 µmol/l, while in healthy women this diagnostic indicator averages 12.98 ± 0.31. The mean homocysteine value in pregnant women with GDM was 42.87±2.26 µmol/l (P≤0.001).

Another specific marker in pregnant women with GDM is the study of cholecalciferol, vitamin 25(OH) D.

Investigating the concentration of vitamin 25 (OH) D in the blood of pregnant women with GDM, it was found that its concentration decreased to an average of 24.7±0.43 ng/ml, while in healthy women it was 32.3±1.4 ng/ml and it was found that the level of significance of the difference between the indicators in the group of pregnant women with GDM and in the control group was p˂0.001, i.e. almost 2 times less. Reference values for the presence of cholecalciferol varied in the range of 30–100 ng/ml. This means that 7 healthy pregnant women out of 36 without GDM had low levels of 25(OH) D vitamin and these were grade 1 obese pregnant women.